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Furthermore, iron overload triggers an oxidative stress cascade that disrupts intestinal immune homeostasis and barrier function in mammalian hosts, leading to gut microbiota dysbiosis characterized by decreased abundance of probiotics (Gu et al., 2023
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Recent single-cell and single-nucleus transcriptomic studies have already delineated more than nine transcriptionally distinct astrocyte clusters, underscoring both the complexity of astrocytic heterogeneity and the inadequacy of traditional binary classification schemes 20,61
It's designed for accelerated tissue healing, injury recovery, and reduced inflammation
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