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Loss of synaptic connections is a major cause of neuronal apoptosis and discourages neurogenesis

Episcleritis Eye redness and irritation or burning without a change in vision Parallels IBD activity and resolves with treatment of underlying bowel inflammation Eye redness or pain and a change in vision in a patient with IBD warrants immediate ophthalmologic evaluation for scleritis or an terior uveitis Ocular Manifestations Hepatobiliary and Pancreatic Manifestations Ocular manifestations of IBD are present in up to 5% of patients (Box 17.3)

182-187 [online] Available at: Miranda, A.M., Steluti, J., Fisberg, R.M

Protein Denaturation ROS oxidize amino acids, disrupt folding, and impair enzyme function

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