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Recently, it has been shown that overexpression of ACSL4 reverses the myocardial protective effect of baicalin on ischemiareperfusion and amplifies the degree of myocardial lipid peroxidation [79]

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N-acetylcysteine (NAC) is the most well-established precursor, supplying cysteineoften the rate-limiting amino acid in glutathione production

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Treatment of aged rat cardiac fibroblasts with NAC or NAC + Gly rose the intracellular GSH content, and notably, the combination of NAC and Gly exerted a better effect [109]