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Biochem Biophys Res Commun 345:646651

If youre interested in healthy agingor have noticed "longevity" and "anti-aging" topics trending more and more on popular podcasts like Andrew Huberman's Huberman Lab NAD+ is likely already on your radar

Choe SA, Kim S, Im C, et al

A meta-analysis of studies using NAC to increase athletic performance found that there were more side effects (none severe) at 20g/day.[ref] High doses of NAC are used in hospitals by IV for reversing acetaminophen toxicity

The presence of CYP51A1 mutations in patients with congenital cataractsoften accompanied by hepatic or neurological symptomssuggests its dual role in ocular development and systemic homeostasis

Any consideration of dose belongs completely within controlled laboratory experiments, institutional review processes, and the oversight of qualified professionals