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Glial contributions to pathology can be primary (for example, astrocytic expression of mutant glial fibrillary acidic protein, GFAP, causing Alexander disease) or secondary, when glial cells react to pathology by mounting context-specific defensive responses
However, continuous chronic liver injury such as non-alcoholic fatty liver disease (NAFLD) and viral infection can lead to sustained activation of quiescent HSC, resulting in persistent hepatocellular damage
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Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials
In the dataset from Govaere et al., more than 200 individual liver biopsies from patients were histologically scored to determine MASLD/MASH stage, followed by RNA-seq for transcriptomic profiling (46) (Figure 6C)
