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doi:10.1016/j.ijgo.2007.08.010 14

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Users combining both approaches typically maintain moderate topical concentrations (1% to 2%) rather than maximum intensity

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At the level of thyroid hormone synthesis, TNF- can directly inhibit the activity of thyroid peroxidase (TPO), and IL-1 stimulates iodothyronine 5-deiodine activity in the liver to affect the metabolism of thyroid hormone (Fujii et al., 1989)