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Treatment Options for Melasma and Sun Spots Topical Treatments For both conditions, first-line treatments often include: Hydroquinone-based creams (prescription-strength) Retinoids Vitamin C serums Kojic acid Azelaic acid Tranexamic acid While these treatments can be effective, especially for mild cases, they typically require consistent long-term use, and results can be limited

In addition, many other individuals are at risk of B12 and folate deficiency as described later in this article