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Moreover, steroid resistance has been reported in 1015% of patients with asthma

In men, it improves sperm quality by increasing motility, concentration, and morphology while reducing oxidative stress

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Notably, although CR does not increase mitochondrial content, the adaptive induction of PGC-1 by CR maintains a functionally efficient electron transport system and mitochondria in skeletal muscle, reflecting the importance of PGC-1 for the ability of dietary restriction to counteract the age-related decrement in mitochondrial respiration