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Provides antioxidant protection for cellular health

Drawbacks of the Current Treatments for Uterine Fibroids Apart from surgeries such as hysterectomy and myomectomy, uterine artery embolization (UAE), and focused ultrasound surgery (FUS), both ultrasound- and magnetic resonance-guided focused ultrasound surgery (USgFUS and MRgFUS) are also the main treatment strategies for UF, with hysterectomy being the only definitive solution for UF

An intravenous dose of 2 mg/kg in mice demonstrated no effect

RSC Adv 8(27):1496714974 Acknowledgements The authors acknowledge ICMR extramural small grant (EMDR/SG/13/2023-2887) for providing financial assistance

M.MukhopadhyayP.MatyasC.TrojnarE.DamadzicR.et al (2024)

Endogenous substances found within cells can be categorized into enzymatic antioxidants, which include superoxide dismutase (SOD), catalases (CAT), and peroxidases, or non-enzymatic antioxidants, which encompass tocopherol, glutathione, and ascorbic acid ( 2 - ) into less reactive molecules, specifically O2 and H 2 O 2 ( 2 O 2 into water ( 2.6 Activation of inflammatory pathways The two main transcription factors that control cellular reactions to oxidative stress and inflammation are nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-B (NF-B) ( 2.6.1 Nrf2 signaling Nrf2 is a crucial transcription factor that plays a significant role in preserving mucosal balance by inhibiting the excessive production of ROS in IBD.Nrf2 has a dampening effect on the inflammatory response and the damage to the mucosal lining through its antioxidant actions ( Figure 2 ) ( IL-1, IL-6, IL-8, iNOS , and COX-2 , and a decrease in the expression of antioxidant enzymes like hemeoxygenase-1 and GST Mu-1 ( Figure 2 2.6.2 NF-B signaling NF-B is a key regulator in many pathogenic processes and is abnormally active in IBD