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Vitamin B12, B6, or folate and cognitive function in community-dwelling older adults: a systematic review and meta-analysis

A 2025 meta-analysis supported some of these claims, finding that collagen peptide supplementation may improve bone mineral density and muscle function

However, B12 shots typically start to show their effects within a few days to a week in most people

Pain may shift from constant to activity-related, then diminish further

Perhaps most telling, researchers tested for anti-AOD 9604 antibodies at multiple timepoints throughout the trials