Glutathione is recruited into the nucleus in early phases of cell proliferation
After mixing with appropriate amount of each amino acid (0.1 M), emission spectra were recorded at room temperature
Any insoluble material was pelleted by centrifugation (13,000 g , 10 min, 4 C) and then 100 l of supernatant CL was transferred to a clean microcentrifuge tube
GSTs have been implicated in the development of resistance toward chemotherapy agents
Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes - Biochem Pharmacol - 1990 Jun 15
The gamma-glutamyl cycle should be considered not as a mechanism for amino acid transport but rather a generator of extracellular signals, gamma-glutamyl amino acids, that are converted intracellularly to 5-oxoproline, which activates uptake and/or metabolism of amino acids ( - glutamyl amino acids or oxoproline could be signaling molecules to activate the transport of amino acids through membranes
