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This heterogeneity and poorly understood neurobiology pose significant challenges to existing drug development paradigms, resulting in scarce treatment options, especially for bipolar depression

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Long term survival analysis of multi-center clinical trial using endoscopy (END) adn endoscopic ultrasound (EUS) guided fine needle injection (FN1) of anti-tumor agent (TNFerade Biologic (TNF)) in patients with locally advanced esophageal cancer

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68 The balance among MMPs and TIMPs (tissue inhibitors of metalloproteinases) are important for the regulation of pathogenesis of Matrix metalloproteinases like MMP-1 (interstitial collagenase), MMP-3 (stromelysin-1) and MMP-13 (collagenase 3) plays an essential part in osteoarthritis based on their capability to cleave components of the ECM in articular cartilage