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In addition, nattokinase was not associated with any adverse reactions or drug interactions (Gallelli 2021)

It is used for peripheral neuropathy (pain in nerves, usually in lower limbs and hands)

Given the potential for placebo effects to persist for long periods, only the data from the first phases were examined if reported (i.e., before the crossover)

Unexplained hypercobalaminemia, particularly levels above 1,000 pg/mL, has been associated with liver disease, kidney dysfunction, myeloproliferative disorders, and certain solid cancers in multiple large-scale studies