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This work was supported by grants from the NIH: R37-AG009909 (JC), the NIA: PPG AG-17242-02 (JC/JH), the Austrian Science Fund: FWF P28854 (TM) and DK-MCD W1226 (TM), the Royal Netherlands Academy of Arts and Sciences (JH), the Erasmus University Medical Center: EMC fellowship 2013 (PDK), the Dutch Kidney Foundation: Grant 15OP11 (RDB&PDK), and the Dutch Cancer Society: fellowship Buit-4649 (PDK) and project grant EMCR 2014-7141 (PDK)

The mechanisms by which metformin modulates endometrial tolerance in PCOS are shown in Figure 2

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doi: 10.1038/nrm2329 59 LiuGYangKBurnsSShresthaSChiH

Vitamin B12 is well-known for its role in energy production