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In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

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The complementary mechanisms of these compounds may support a more comprehensive neurological environment than any single peptide alone

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Previous studies have also found that knockout mice for GXP-3, the enzyme that uses GSH to lower ROS, demonstrate increased platelet-induced microthrombosis [29]

In the present work, we established a rat model of SCI and then administered GlyNAC to the animals by gavage at a dose of 200 mg/kg for four consecutive weeks