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Notably, in the condition of excess hemin exposure and hypoxia, our findings suggest an important contribution of the TSS pathway and its regulation by DMF for de novo cysteine synthesis and GSH generation in protecting against the oxidative and ferroptotic stresses in SCD erythroblasts

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As the literature expands on the links between gut dysbiosis and the broader symptomatology of ME/CFS, it becomes increasingly necessary to integrate this knowledge into clinical practice, reinforcing perspectives that prioritize holistic treatment methodologies in an often fragmented care landscape

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Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets