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These interwoven networks highlight the reciprocal relationship between obesity, endocrine dysfunction, and reproductive health, underscoring the necessity for focused therapies to alleviate these impacts

Medical conditions like anaemia, hypothyroidism and polycystic ovarian syndrome can also increase pigmentation

All agents discussed in this section are shown in Figure 6B

Although OA pathogenesis is exceedingly complex, recent studies underscore the multifactorial nature of the disease, involving mechanical overload, inflammatory responses, metabolic abnormalities, and cell death ( Cartilage deterioration and subchondral bone remodeling are hallmarks of OA

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16 Dysregulated mitochondrial ROS production is a feature of smokers with COPD 17,18 that is not limited to the lungs