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In the phase 2 dose-finding trial involving 706 participants, nausea rates varied dramatically by dose

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Without offering a citation for a published paper or sharing any data, Sikirics 2025 review states that this clinical trial found that the drug was safe and well-tolerated in humans

The NO/VEGFR2/Akt-eNOS Pathway One of the most frequently cited mechanisms involves the nitric oxide (NO) signaling pathway and vascular endothelial growth factor receptor 2 (VEGFR2)