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This is consistent with the approach recommended for anyone following the standard tirzepatide dosing schedule for weight loss

By Day 45, reduced CYP expression correlated with the emergence of mesenchymal-like cells, although functional hepatocytes remained, as evidenced by continued ALB localization in immunostaining analyses

This is not duplication it is genuinely complementary pharmacology operating on different receptor systems in different neural circuits

None of them are introducing a foreign mechanism

And to be honest with you, I don't yet have a great answer