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Sub-visible particulates are, by definition, below the threshold of visual detection

It could be a sensitivity or a paradoxical reaction if their detoxification pathways are congested (including the interstitium and liver)

Theoretically, the intracellular assimilation of folic acid via dihydrofolate reductase might enhance thymidylate synthetase by bypassing the methylfolate trap, thereby allowing cellular proliferation to progress temporarily

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The key factors are the date of the first puncture and proper handling, not the volume of the vial

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