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The affected limb may need to be amputated if these skin ulcers do not heal, or become larger, deeper, or infected
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In addition, the absence of resistance of peptides to breakdown by gastrointestinal proteolytic enzymes (e.g., carboxypeptidases or aminopeptidases) should be mentioned [8], which in practice precludes administrating such a drug to the patient orally and calls for intravenous administration
Mood disturbances, such as anxiety, depression, and irritability: These mental health symptoms can indicate a severe deficiency
Typical endpoints include lesion size reduction, mucosal histology, and markers of epithelial repair
Mechanism of Action GHK-Cu exerts its biological effects through multiple interconnected mechanisms, acting both as a signalling molecule and a copper delivery system
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