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and a thicker and loosely outer layer rich of bacteria and bacterial products

So, they introduce pure alcohol into the system much faster than lower-ABV drinks like light beer

Lally JSV, Ghoshal S, DePeralta DK, et al

For instance, miR-361-5p regulates the translocation of GLUT1 from the plasma membrane to the cytoplasm, thus reducing anaerobic glycolysis, proliferation and invasion