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Some foods help strengthen the intestinal lining, while others may cause irritation and inflammation

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The clinical presentation ranges from only loose stools to toxic megacolon (nausea, vomiting, high-grade fever, and ileus) and colonic perforation

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Studies using GLP-1R and GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) knockout mice further show that loss of these receptors exaggerates allergen-induced airway inflammation, demonstrating that endogenous incretin receptor signaling normally limits type 2 innate immune responses [107]