Most peptides are degraded in the GI tract before they can exert biological effects, but KPVs small size (three amino acids) and PepT1 affinity allow it to reach intestinal tissue intact
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So if someone is low in B12 and they consume alcohol, they not only don't have enough B12 to help 'clear away' the alcohol toxins but they also risk increasing homocysteine levels which I believe is that feeling of heat/hangover that can persist when there isn't enough B12 to reset the body
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The bright blue colour is entirely natural and comes from the copper ions binding to the peptide chains
For a lot of people, the first signs are quite subtle