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these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

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Liraglutide was the first widely adopted GLP-1 agonist, though it requires daily rather than weekly dosing

Standard dosing ranges from 0.25 mg to 0.5 mg daily via subcutaneous injection

However, the orthopaedic community has been reluctant to recommend surgical intervention except for the most severe cases because the outcomes of this surgery are not as predictable as we would like

For gut health specifically, oral is the preferred route for direct tissue contact