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Importantly, the same authors also reported that AML cells were unable to synthetize cysteine from methionine providing an opportunity to exploit this vulnerability for AML treatment

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Partial pressure of oxygen (PO2) and carbon dioxide (PCO2) in arterial blood of animals were checked to confirm induction of hypoxia

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Furthermore, substances produced by renal cancer cells, such as lactic acid and ROS, can cause damage to immune cells and reduce their antitumor effect (382)