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Furthermore, our recent work indicates that the viral overexpression of NRF2 in the rodent SVZ can mitigate the decline in NSC function across the critical middle-age period ( Nrf2 / mice have decreased clonogenic and neurogenic potential, as well as an impaired capacity for long-term progression from birth to adulthood in Nrf2 / mice compared to wild-type controls (Robledinos-Antn et al., 2017)
The body's antioxidant defense system is complex and relies on numerous nutrients and compounds working together
doi: 10.1038/ni835 128 LanzT
At the same time, it was found in vivo that after OTA treatment, lipid peroxide (LPO) was significantly increased in the liver, and GSH, SOD, CAT, GR, and GSH-Px were significantly decreased, indicating that the antioxidant capacity of the liver was decreased and toxicity was activated under the influence of OTA [33]
