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The results showed that the PGRMC1 dimer is not dissociated into monomer at all concentrations examined (Supplementary Fig

Furthermore, chronic, low-grade inflammation triggered by LPS-induced activation of TLR4-NF-B impairs insulin signaling, enhances lipogenesis and adipocyte hypertrophy, promoting lipid accumulation and metabolic dysregulation [221]

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Contrary to earlier claims of complete harmlessness, recent clinical reports have linked ashwagandha to cases of clinically apparent liver injury, placing it among a growing group of herbal and dietary supplements (HDS) with recognized hepatotoxic potential [229]