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EA inhibits GST- , - , and - by binding directly to the substrate-binding site of the isozyme, as well as by depleting its cofactor, GSH, via conjugation of the Michael addition intermediate to the thiol group of GSH (Mulder et al ., 1997

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L-Glutamine (CHNO) is the most abundant free amino acid in the human body, particularly in skeletal muscle

This small molecule compound was developed through sophisticated structure-guided design and binding calculations as part of a systematic effort to create membrane-permeable NNMT inhibitors with enhanced potency and selectivity

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