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As for the more general TKIs the sequence homology between IGF-1R and IR-A/B kinase domains presented a major problem and therefore side effects were of great concern (Guha, 2013)

Hub genes were subsequently analyzed for enrichment, proteinprotein interactions (PPIs), and different immunological microenvironments, and potential hub gene were identified using MCC method and LASSO

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Research progress on the mechanism of retinal light injury