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New York, NY: Agency for Healthcare Research and Quality (2011)

In acute overdose or when the maximum daily dose is exceeded over a prolonged period, metabolism by conjugation becomes saturated, and excess APAP is oxidatively metabolized by the CYP enzymes 2E1, 1A2, 2A6, and 3A4 to the hepatotoxic reactive metabolite N -acetyl- p -benzoquinone imine (NAPQI)

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Further exploration of the interregulation of various types of cell death can provide insights into the role of regulatory cell death in cancer