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However, scientists still need larger human clinical trials to confirm its long-term safety and effectiveness

Proc Natl Acad Sci Usa 2022;119:e2206053119

Sci Pharm (2015) 83:15975

Psychological stress-induced modulation of interleukin 2 receptor gene expression and interleukin 2 production in peripheral blood leukocytes

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Butyrate also can cross into the bloodstream and reach the brain, where it serves as an energy substrate for neurons and glia and as an epigenetic regulator (through inhibition of histone deacetylases) [76]