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302 Notably, microbial metabolites produced by commensal gut flora can limit pathogenic activities of microglia and astrocytes and suppress CNS inflammation in MS experimental models 303 and can contribute to the induction of specific LAMP1+TRAIL+ astrocytes that limit CNS inflammation by inducing T cell apoptosis

This process induces the upregulation of AQP4 and causes swelling in the astrocytic end-feet [131]

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

Likewise, the elevated levels of ferritin activate proinflammatory signaling through NF- with a later increase of interleukins, principally IL-1 [5]

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