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MDA, a byproduct of lipid peroxidation, serves as a key biomarker of OS and exhibits cytotoxic effects on spermatozoa

However, developing new drugs based on the new theory involves various stakeholders such as the government, venture capital, pharmaceutical companies, hospitals, and patients

Nasal administration, on the other hand, works through a completely different mechanism

Senescent cells usually leak lots of nasty chemicals that cause inflammation and damage in our bodies and can also develop into tumors

Consequently, keratinocyte hyperactivation and immune dysregulation are initiated, establishing a self-perpetuating cycle of barrier disruption and inflammatory amplification that ultimately drives disease progression (Katsarou et al., 2023

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