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Protection against Chemotherapy-Induced Toxicity: Chemotherapy is a common treatment for cancer, but it often causes significant side effects

These reagents support two clinically relevant concepts: (1) Combination sensitization: FSP1 blockade can sensitize tumors to upstream ferroptosis-inducing nodes (for example, GPX4 inhibition or cystine import disruption), consistent with the idea that tumors rely on redundant antioxidant systems

Many OXPHOS inhibitors or SHMT2 inhibitors exhibit narrow therapeutic windows and significant side effects [187]

& Hartl, F

While the ROS induces unsaturated lipid peroxidation, it yields the highly reactive lipid peroxyl radicals, which are quickly neutralized by -tocopherol through the donation of its hydrogen to the peroxyl radicals, thus holding their propagations within membranes and circulating lipoproteins

Indeed, Redox equilibrium is important for the maintenance of various vital aspects of sperm functionality