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For most users it is a tolerability nuisance rather than a safety concern, and it resolves on lowering or stopping the dose

The scaffolds synthesized by this method do not require high temperatures [96], but the crosslinking agents may be harmful to organisms

Matrix Biol 64:112127 Mogler C et al (2015) Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage

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