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A plausible explanation could be a reorientation of Lys105 towards GS resulting in a decreased stabilization of the active site thiolate as a leaving group

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10.1146/annurev-psych-010418-102803 46 SuL.LiP.LuT.MaoC.JiD.HaoM.et al (2019)

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Talib, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Research shows that skin-applied cannabis, which largely stays on the skin surface, is relatively safe