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10.1208/s12248-009-9128-x AAPS J

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Activated caspase-8 subsequently triggers caspase-3, leading to cell death

Reconstituted injectable GHK-Cu: 2-8C (refrigerated): 28-30 days stable 15-25C (room temp): Degrades in 3-7 days 30C (warm): Degrades in 24-48 hours Topical serum (opened): 2-8C (refrigerated): 6-12 months 15-25C (room temp): 3-6 months 30C (warm environment): 1-3 months Raw powder (sealed): 2-8C (refrigerated): 24-36 months 15-25C (room temp): 12-24 months 30C (warm): 6-12 months Key takeaway: Every 10C increase in temperature roughly doubles the degradation rate

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[ 8 ] In humans, one study found that DSIP reduced circulating ACTH levels, while another found no effect on CRH-stimulated ACTH and cortisol secretion