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Emerging/Translational Insights Metabolic health targets
Study Design Type: Phase 2, double-blind, randomized, placebo-controlled study Participants: 338 adults (BMI 30 or BMI 27 with a coexisting condition) Groups: Retatrutide 1 mg, 4 mg, 8 mg, 12 mg (different initial doses 2 or 4 mg) and placebo Duration: 48 weeks (plus 4 weeks follow-up) Administration: subcutaneous, 1x weekly Primary endpoint: percentage change in body weight at week 24 Secondary endpoints: change in weight at week 48, 5%, 10%, 15% weight reduction
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In addition, Fer-1 significantly inhibits the production of cytoplasmic and lipid ROS and reverses Glu-induced suppression of GSH and Gpx in HT-22 cells, suggesting that Fer-1 protects HT-22 cells by blocking oxidative toxicity
