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10.1016/j.tins.2011.05.004 Trends Neurosci

5FU adaptation alters mitochondrial activity Given the changes in mitochondrial abundance, without evident mitochondrial dysfunction (no cristae clearing, no change in apoptotic priming, no release of cytochrome c or mtDNA), we reasoned that the increase might be associated with increased functionality

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The hormone starts acting quickly, but symptom improvements (such as in energy or libido) may take a few weeks