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Both intact drug and drug metabolites are then transported to the liver, where they can be further metabolized before reaching systemic circulation and reducing the drugs bioavailability

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Knowing which metric moved, and whether it rose above baseline or only fell more slowly, is what separates a lasting result from a temporary one, which is also why measuring brain aging across several markers at once gives a steadier read than any single number

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PR, Progesterone receptor

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