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Screening and identification of key biomarkers associated with amyotrophic lateral sclerosis and depression using bioinformatics

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Additionally, isobavachin (derived from Pittosporum species) acts as a human urate transporter 1 (hURAT1) inhibitor, blocking urate reabsorption to reduce SUA levels, akin to the mechanism of tranilast ( 3.4.3 Exploratory non-pharmacological approaches Non-pharmacological approaches serve as essential adjuncts for hyperuricemia management, particularly in asymptomatic individuals (Zhang et al., 2012

4.1 Natural products remodel tumor microenvironment through immune cell metabolic reprogramming With increasing insights into the mechanisms by which natural products modulate metabolism in cancer, studies have found that these natural products have the potential to reshape the TME by reprogramming immune cell metabolism and restoring antitumor immunity

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