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Infection, injury, autoimmune activity, obesity, smoking, and other conditions may raise it

Needle electromyographic examination of the external anal sphincter provides a sensitive measure of denervation and usually can identify myopathic, neurogenic, or mixed injury

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24 A meta-analysis of six trials comparing NSAIDs with placebo had similar limitations but found significant short-term pain relief with NSAIDs in patients with chronic low back pain

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Cardiovascular Applications TB-500 has demonstrated significant cardiovascular benefits in preclinical investigations, particularly in models of myocardial injury and cardiac remodeling