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Sigma-1 receptors can also exert antidepressant effects through modulating serotonin 5-HT 1A function or modulation of the endoplasmic reticulum stress response, thus facilitating BDNF expression [130]

Additionally, Engel et al

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however, the exact balance of (exogenous) antioxidant supplementation to ROS levels that may enhance performance without blunting adaptive pathways is currently unknown