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doi: 10.1074/jbc.M109.059782 69 da CostaPEBatistaWLMoraesMSSternAMonteiroHP

In recent years, the role of ferroptosis as a novel cell death modality in CHD has gradually gained recognition

Most excitatory signals are mediated by glutamate, the major neurotransmitter in the mammalian central nervous system [219]

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Under pathological conditions, FUNDC1 persists in a phosphorylated state that specifically impedes its molecular interaction with the autophagosomal marker protein LC3-II, consequently suppressing mitophagy initiation and ultimately inducing neuronal dysfunction ( Mitochondrial fragmentation has also been demonstrated in AD patients and model animals