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Instead, its activity is believed to be mediated via adipocyte-specific signaling cascades, which gives the fragment a uniquely narrow pharmacological footprint for a peptide of its molecular size and makes it attractive to investigators who want clean lipolytic readouts

animal and investigational data only, no approved indication

Although glucagon action is primarily liver specific, glucagon receptors have been reported to be present in membranes of human adipose tissue (83), suggesting that direct action of glucagon likely plays an important role in regulating human, as well as rodent, lipolysis

Together they attack fat from two angles, burning existing stores and improving how your body uses energy

John DiBella Published: November 3, 2025 Fact-checked by Dr

The amino acid sequence is Gly-His-Lys