The apolipoprotein E4 genotype contributes to the abnormal accumulation of lipid droplets (LD) in microglia and the formation of neurotoxic LD-accumulating microglia, which are capable of directly inducing neuronal Tau phosphorylation and apoptosis, and the degree of LD accumulation is positively correlated with the severity of cognitive decline and pathology [148]
Eloralintide is still being tested in large-scale studies, with results expected around 2028
Body composition & lipolysis Explored in research on how growth-hormone signaling relates to fat breakdown and lean-mass shifts
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