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The molecular and genetic mechanisms involved in HD are well understood, but available therapies mostly treat symptoms rather than addressing the underlying cause of this condition (56)

Plasma and extracellular pools of reduced GSH are much lower than the intracellular pool, around 1-10 M at the exception of bile (10 mM, Meister and Anderson 1983, Ballaroti et al

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Acknowledgements Authors want to thank American Centre of Reproductive Medicine for providing support for the study

doi:10.1016/j.rbmo.2020.08.013