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Both regional gray-matter and white-matter changes appear to be present relatively early in disease development

miR-122 can promote hepatic lipogenesis by inhibiting the liver kinase B1 (LKB1)/5 adenosine monophosphate-activated protein kinase (AMPK) signaling pathway through direct targeting of sirtuin 1 (SIRT1) [291]

doi: 10.1359/jbmr.1997.12.3.431 81

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Wilkinson JL, Boxall ABA, Kolpin DW, Leung KMY, Lai RWS, Galbn-Malagn C, et al