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NCX4040, targeting CHAC1 and GPX4, induces ferroptosis in Ras-mutated CRC cells, suggesting future applications in oxidative stress-focused therapies

Furthermore, we performed immunostaining for F4/80 (mature macrophage marker protein) to confirm that the infiltration of immune cells into the large intestine of the Si-DSS group were less than that in the control group

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2 NEUs regulate the intestinal inflammation of UC 2.1 NEU-derived ROS and NETs exacerbate intestinal inflammation NEUs are essential effectors of innate immunity, yet their excessive activation has been implicated in the onset and progression of various autoimmune diseases (9, 10)

Cystine restriction elevated the level of phospho-eIF2 (S51) and ATF4 (Fig